Nature Communications (Aug 2019)
Nobiletin fortifies mitochondrial respiration in skeletal muscle to promote healthy aging against metabolic challenge
- Kazunari Nohara,
- Venkata Mallampalli,
- Travis Nemkov,
- Marvin Wirianto,
- Jiah Yang,
- Youqiong Ye,
- Yuxiang Sun,
- Leng Han,
- Karyn A. Esser,
- Eugenia Mileykovskaya,
- Angelo D’Alessandro,
- Carla B. Green,
- Joseph S. Takahashi,
- William Dowhan,
- Seung-Hee Yoo,
- Zheng Chen
Affiliations
- Kazunari Nohara
- Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston
- Venkata Mallampalli
- Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston
- Travis Nemkov
- Department of Biochemistry and Molecular Genetics, University of Colorado Denver - Anschutz Medical Campus
- Marvin Wirianto
- Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston
- Jiah Yang
- Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston
- Youqiong Ye
- Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston
- Yuxiang Sun
- Department of Nutrition and Food Science, Texas A&M University
- Leng Han
- Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston
- Karyn A. Esser
- Department of Physiology and Functional Genomics, University of Florida College of Medicine
- Eugenia Mileykovskaya
- Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston
- Angelo D’Alessandro
- Department of Biochemistry and Molecular Genetics, University of Colorado Denver - Anschutz Medical Campus
- Carla B. Green
- Department of Neuroscience, The University of Texas Southwestern Medical Center
- Joseph S. Takahashi
- Department of Neuroscience, The University of Texas Southwestern Medical Center
- William Dowhan
- Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston
- Seung-Hee Yoo
- Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston
- Zheng Chen
- Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston
- DOI
- https://doi.org/10.1038/s41467-019-11926-y
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 15
Abstract
The small molecule Nobiletin enhances circadian rhythms and protects against obesity-associated metabolic dysfunction in mice. Here the authors test its effect on health and lifespan, reporting that circadian enhancement promotes fitness and healthy aging in metabolically challenged mice.
