Plasma TIMP-1 as a sex-specific biomarker for acute lung injury

Abstract

Highlights Plasma TIMP-1 levels are significantly elevated in ARDS patients. Plasma TIMP-1 levels show no difference between female and male ARDS patients. Considering the 30 and 90-day mortality, female non-survivors have significantly higher plasma TIMP-1 levels compared to female survivors. However, there is no difference between non-survivors and survivors in the male group. Plasma TIMP-1 levels demonstrate an excellent discriminating ability for the prediction of mortality among female ARDS patients. The high TIMP-1 level group shows worse other relevant clinical outcomes, VFDs, and ICU-free days.

Keywords

• Acute respiratory distress syndrome
• Mortality
• Matrix metalloproteinases
• Critical illness