PLoS Neglected Tropical Diseases (Feb 2023)

Serum biomarkers and anti-flavivirus antibodies at presentation as indicators of severe dengue.

  • Cynthia Bernal,
  • Sara Ping,
  • Alejandra Rojas,
  • Oliver Caballero,
  • Victoria Stittleburg,
  • Yvalena de Guillén,
  • Patricia Langjahr,
  • Benjamin A Pinsky,
  • Marta Von-Horoch,
  • Patricia Luraschi,
  • Sandra Cabral,
  • María Cecilia Sánchez,
  • Aurelia Torres,
  • Fátima Cardozo,
  • Jesse J Waggoner

DOI
https://doi.org/10.1371/journal.pntd.0010750
Journal volume & issue
Vol. 17, no. 2
p. e0010750

Abstract

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BackgroundDengue is the most common vector-borne viral disease worldwide. Most cases are mild, but some evolve into severe dengue (SD), with high lethality. Therefore, it is important to identify biomarkers of severe disease to improve outcomes and judiciously utilize resources.Methods/principal findingsOne hundred forty-five confirmed dengue cases (median age, 42; range ConclusionsMultiple, readily available factors were associated with SD in this population. These findings will aid in the early detection of potentially severe dengue cases and inform the development of new prognostics for use in acute-phase and serial samples from dengue cases.