Everolimus‐induced gastric antral vascular ectasia in advanced renal cancer

Abstract

Introduction Although several medical, endoscopic, and surgical treatment options are available, the management of gastric antral vascular ectasia remains clinically challenging. We report a case of gastric antral vascular ectasia due to everolimus use in a patient with advanced renal cancer. Case presentation A 71‐year‐old man was diagnosed with right‐sided renal cancer and multiple lung metastases. In the period of everolimus as third‐line therapy, endoscopy of the upper gastrointestinal tract revealed everolimus‐induced gastric antral vascular ectasia. Endoscopic argon plasma coagulation and variceal ligation were repeated seven times within a month of everolimus cessation. Subsequently, an antrectomy was performed; his postoperative course was uneventful. Conclusion Based on our experience, we believe that an antrectomy is important in the management of mammalian target of rapamycin inhibitor‐related gastric antral vascular ectasia.

Keywords

• adverse event
• everolimus
• gastric antral vascular ectasia
• GAVE
• renal cancer