Communications Biology (Dec 2020)

Genetic ancestry, skin pigmentation, and the risk of cutaneous squamous cell carcinoma in Hispanic/Latino and non-Hispanic white populations

  • Eric Jorgenson,
  • Hélène Choquet,
  • Jie Yin,
  • Thomas J. Hoffmann,
  • Yambazi Banda,
  • Mark N. Kvale,
  • Neil Risch,
  • Catherine Schaefer,
  • Maryam M. Asgari

DOI
https://doi.org/10.1038/s42003-020-01461-8
Journal volume & issue
Vol. 3, no. 1
pp. 1 – 9

Abstract

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Eric Jorgenson and Hélène Choquet et al. find that northwestern European genetic ancestry is associated with increased risk of cutaneous squamous cell carcinoma (cSCC) in non-Hispanic whites, and more so in Hispanic/Latinos of the US. The ancestry effect is largely, but not entirely explained by genetic determinants of skin pigmentation in both populations.