Nature Communications (May 2018)

Cell of origin and mutation pattern define three clinically distinct classes of sebaceous carcinoma

  • Jeffrey P. North,
  • Justin Golovato,
  • Charles J. Vaske,
  • J. Zachary Sanborn,
  • Andrew Nguyen,
  • Wei Wu,
  • Benjamin Goode,
  • Meredith Stevers,
  • Kevin McMullen,
  • Bethany E. Perez White,
  • Eric A. Collisson,
  • Michele Bloomer,
  • David A. Solomon,
  • Stephen C. Benz,
  • Raymond J. Cho

DOI
https://doi.org/10.1038/s41467-018-04008-y
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 9

Abstract

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Sebaceous carcinomas (SeC) are cutaneous malignancies that sometimes metastasize and cause death. Here the authors perform whole-exome sequencing on 32 SeC and report distinct mutational classes that may explain cancer ontogeny and clinical outcome.