Frontiers in Endocrinology (Mar 2024)
Phenotype of early-onset fetal growth restriction in sheep
- Amy E. Sutherland,
- Amy E. Sutherland,
- Tegan A. White,
- Tegan A. White,
- Charmaine R. Rock,
- Charmaine R. Rock,
- Beth R. Piscopo,
- Beth R. Piscopo,
- Ingrid Dudink,
- Ingrid Dudink,
- Ishmael M. Inocencio,
- Ishmael M. Inocencio,
- Zahrah Azman,
- Zahrah Azman,
- Yen Pham,
- Yen Pham,
- Ilias Nitsos,
- Ilias Nitsos,
- Atul Malhotra,
- Atul Malhotra,
- Atul Malhotra,
- Tamara Yawno,
- Tamara Yawno,
- Tamara Yawno,
- Graeme R. Polglase,
- Graeme R. Polglase,
- Graham Jenkin,
- Graham Jenkin,
- Emily J. Camm,
- Emily J. Camm,
- Beth J. Allison,
- Beth J. Allison,
- Suzanne L. Miller,
- Suzanne L. Miller
Affiliations
- Amy E. Sutherland
- The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, VIC, Australia
- Amy E. Sutherland
- Department of Obstetrics and Gynaecology, Monash University, Melbourne, VIC, Australia
- Tegan A. White
- The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, VIC, Australia
- Tegan A. White
- Department of Obstetrics and Gynaecology, Monash University, Melbourne, VIC, Australia
- Charmaine R. Rock
- The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, VIC, Australia
- Charmaine R. Rock
- Department of Obstetrics and Gynaecology, Monash University, Melbourne, VIC, Australia
- Beth R. Piscopo
- The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, VIC, Australia
- Beth R. Piscopo
- Department of Obstetrics and Gynaecology, Monash University, Melbourne, VIC, Australia
- Ingrid Dudink
- The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, VIC, Australia
- Ingrid Dudink
- Department of Obstetrics and Gynaecology, Monash University, Melbourne, VIC, Australia
- Ishmael M. Inocencio
- The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, VIC, Australia
- Ishmael M. Inocencio
- Department of Obstetrics and Gynaecology, Monash University, Melbourne, VIC, Australia
- Zahrah Azman
- The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, VIC, Australia
- Zahrah Azman
- Department of Obstetrics and Gynaecology, Monash University, Melbourne, VIC, Australia
- Yen Pham
- The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, VIC, Australia
- Yen Pham
- Department of Obstetrics and Gynaecology, Monash University, Melbourne, VIC, Australia
- Ilias Nitsos
- The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, VIC, Australia
- Ilias Nitsos
- Department of Obstetrics and Gynaecology, Monash University, Melbourne, VIC, Australia
- Atul Malhotra
- The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, VIC, Australia
- Atul Malhotra
- Department of Paediatrics, Monash University, Melbourne, VIC, Australia
- Atul Malhotra
- Monash Newborn, Monash Children’s Hospital, Melbourne, VIC, Australia
- Tamara Yawno
- The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, VIC, Australia
- Tamara Yawno
- Department of Obstetrics and Gynaecology, Monash University, Melbourne, VIC, Australia
- Tamara Yawno
- Department of Paediatrics, Monash University, Melbourne, VIC, Australia
- Graeme R. Polglase
- The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, VIC, Australia
- Graeme R. Polglase
- Department of Obstetrics and Gynaecology, Monash University, Melbourne, VIC, Australia
- Graham Jenkin
- The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, VIC, Australia
- Graham Jenkin
- Department of Obstetrics and Gynaecology, Monash University, Melbourne, VIC, Australia
- Emily J. Camm
- The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, VIC, Australia
- Emily J. Camm
- Department of Obstetrics and Gynaecology, Monash University, Melbourne, VIC, Australia
- Beth J. Allison
- The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, VIC, Australia
- Beth J. Allison
- Department of Obstetrics and Gynaecology, Monash University, Melbourne, VIC, Australia
- Suzanne L. Miller
- The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, VIC, Australia
- Suzanne L. Miller
- Department of Obstetrics and Gynaecology, Monash University, Melbourne, VIC, Australia
- DOI
- https://doi.org/10.3389/fendo.2024.1374897
- Journal volume & issue
-
Vol. 15
Abstract
IntroductionFetal growth restriction (FGR) is a common pregnancy complication, caused by placental insufficiency, with serious adverse consequences for development in utero and postnatal wellbeing. There are no antenatal treatments to improve growth or organ development in FGR, and animal models are essential to mimic the physiological adaptations in FGR and to assess potential interventions. This study aimed to identify the temporal nature of reduced developmental trajectory in fetuses with FGR, and to examine the effects of common factors that may mediate differential growth such as glucocorticoid treatment. We hypothesised that the trajectory of growth would be adversely impacted by FGR.MethodsFGR was induced via surgical placental insufficiency in fetal sheep (89 days gestation/0.6 gestation; n=135) and compared to age-matched controls over the last third of gestation and into neonatal life (n=153).ResultsBody weight of FGR fetuses/lambs was significantly reduced compared to controls (p<0.0001) from 127 days of gestation (term is 148 days), with increased brain:body weight ratio (p<0.0001) indicative of brain sparing. All biometric measures of body size were reduced in the FGR group with the exception of biparietal (head) diameter. The trajectory of body growth in the last trimester of sheep pregnancy was significantly reduced in the FGR group compared to controls, and stillbirth rate increased with longer gestation.DiscussionThis work provides a well characterised FGR animal model that mimics the known physiological adaptations in human pregnancy and can be used to determine the efficacy of potential interventions.
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