The RSV F p27 peptide: current knowledge, important questions

Wanderson Rezende; Wanderson Rezende; Hadley E. Neal; Rebecca E. Dutch; Pedro A. Piedra; Pedro A. Piedra

doi:10.3389/fmicb.2023.1219846

Frontiers in Microbiology (Jun 2023)

The RSV F p27 peptide: current knowledge, important questions

Wanderson Rezende,
Wanderson Rezende,
Hadley E. Neal,
Rebecca E. Dutch,
Pedro A. Piedra,
Pedro A. Piedra

Affiliations

Wanderson Rezende: Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, United States
Wanderson Rezende: Department of Pharmacology, Baylor College of Medicine, Houston, TX, United States
Hadley E. Neal: Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY, United States
Rebecca E. Dutch: Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY, United States
Pedro A. Piedra: Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, United States
Pedro A. Piedra: Department of Pediatrics, Baylor College of Medicine, Houston, TX, United States

DOI: https://doi.org/10.3389/fmicb.2023.1219846
Journal volume & issue: Vol. 14

Abstract

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Respiratory syncytial virus (RSV) remains a leading cause of hospitalizations and death for young children and adults over 65. The worldwide impact of RSV has prioritized the search for an RSV vaccine, with most targeting the critical fusion (F) protein. However, questions remain about the mechanism of RSV entry and RSV F triggering and fusion promotion. This review highlights these questions, specifically those surrounding a cleaved 27 amino acids long peptide within F, p27.

Published in Frontiers in Microbiology

ISSN: 1664-302X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Microbiology
Website: http://www.frontiersin.org/journals/microbiology

About the journal

Abstract

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