Structural basis for ligand recognition of the neuropeptide Y Y2 receptor

Tingting Tang; Christin Hartig; Qiuru Chen; Wenli Zhao; Anette Kaiser; Xuefeng Zhang; Hui Zhang; Honge Qu; Cuiying Yi; Limin Ma; Shuo Han; Qiang Zhao; Annette G. Beck-Sickinger; Beili Wu

doi:10.1038/s41467-021-21030-9

Nature Communications (Feb 2021)

Structural basis for ligand recognition of the neuropeptide Y Y2 receptor

Tingting Tang,
Christin Hartig,
Qiuru Chen,
Wenli Zhao,
Anette Kaiser,
Xuefeng Zhang,
Hui Zhang,
Honge Qu,
Cuiying Yi,
Limin Ma,
Shuo Han,
Qiang Zhao,
Annette G. Beck-Sickinger,
Beili Wu

Affiliations

Tingting Tang: CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Christin Hartig: Institute of Biochemistry, Faculty of Life Sciences, Leipzig University
Qiuru Chen: CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Wenli Zhao: CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Anette Kaiser: Institute of Biochemistry, Faculty of Life Sciences, Leipzig University
Xuefeng Zhang: CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Hui Zhang: CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Honge Qu: CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Cuiying Yi: CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Limin Ma: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Shuo Han: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Qiang Zhao: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Annette G. Beck-Sickinger: Institute of Biochemistry, Faculty of Life Sciences, Leipzig University
Beili Wu: CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences

DOI: https://doi.org/10.1038/s41467-021-21030-9
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 9

Abstract

Read online

The human neuropeptide Y receptor Y2 (Y2R) is a drug target for the treatment of obesity and anxiety. Crystal structure of Y2R bound to a selective antagonist and accompanying mutagenesis provide insights into ligand recognition and subtype specificity of NPY receptors.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal