Nature Communications (Sep 2019)
Genetic architecture of human plasma lipidome and its link to cardiovascular disease
- Rubina Tabassum,
- Joel T. Rämö,
- Pietari Ripatti,
- Jukka T. Koskela,
- Mitja Kurki,
- Juha Karjalainen,
- Priit Palta,
- Shabbeer Hassan,
- Javier Nunez-Fontarnau,
- Tuomo T. J. Kiiskinen,
- Sanni Söderlund,
- Niina Matikainen,
- Mathias J. Gerl,
- Michal A. Surma,
- Christian Klose,
- Nathan O. Stitziel,
- Hannele Laivuori,
- Aki S. Havulinna,
- Susan K. Service,
- Veikko Salomaa,
- Matti Pirinen,
- FinnGen Project,
- Matti Jauhiainen,
- Mark J. Daly,
- Nelson B. Freimer,
- Aarno Palotie,
- Marja-Riitta Taskinen,
- Kai Simons,
- Samuli Ripatti
Affiliations
- Rubina Tabassum
- Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki
- Joel T. Rämö
- Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki
- Pietari Ripatti
- Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki
- Jukka T. Koskela
- Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki
- Mitja Kurki
- Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki
- Juha Karjalainen
- Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki
- Priit Palta
- Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki
- Shabbeer Hassan
- Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki
- Javier Nunez-Fontarnau
- Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki
- Tuomo T. J. Kiiskinen
- Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki
- Sanni Söderlund
- Research Programs Unit, Diabetes & Obesity, University of Helsinki and Department of Internal Medicine, Helsinki University Hospital
- Niina Matikainen
- Research Programs Unit, Diabetes & Obesity, University of Helsinki and Department of Internal Medicine, Helsinki University Hospital
- Mathias J. Gerl
- Lipotype GmbH
- Michal A. Surma
- Lipotype GmbH
- Christian Klose
- Lipotype GmbH
- Nathan O. Stitziel
- Cardiovascular Division, Department of Medicine, Washington University School of Medicine
- Hannele Laivuori
- Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki
- Aki S. Havulinna
- Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki
- Susan K. Service
- Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California
- Veikko Salomaa
- National Institute for Health and Welfare
- Matti Pirinen
- Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki
- FinnGen Project
- Matti Jauhiainen
- National Institute for Health and Welfare
- Mark J. Daly
- Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki
- Nelson B. Freimer
- Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California
- Aarno Palotie
- Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki
- Marja-Riitta Taskinen
- Research Programs Unit, Diabetes & Obesity, University of Helsinki and Department of Internal Medicine, Helsinki University Hospital
- Kai Simons
- Lipotype GmbH
- Samuli Ripatti
- Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki
- DOI
- https://doi.org/10.1038/s41467-019-11954-8
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 14
Abstract
Cardiovascular diseases (CVD) are associated with plasma lipid levels. Here, Tabassum et al. perform genome-wide association studies for lipidomic profiles with 141 (non-standard) lipid species which highlights shared genetic loci with CVD and that traditional lipids have low genetic correlation with other lipids.
