Al Ameen Journal of Medical Sciences (Apr 2019)
Histopathological study of the coronary arteries in young individuals and its relation to their age, in a tertiary care hospital in Kolkata, West Bengal
Abstract
Background: Coronary artery disease (CAD) is a leading cause of death of women and men worldwide. Global in distribution, atherosclerosis is emerging as the single largest disease accounting for nearly one-third of all deaths in India. Objectives: A Post-mortem study done to evaluate the incidence of CAD in the Young Individuals and to correlate it with their age. Methodology: In the present study heart specimen from 55 bodies were selected, over a period of one year (randomly selected based on the inclusion and exclusion criteria), which were sent to the Department of Forensic Medicine & Toxicology, NRS Medical College, Kolkata for medicolegal autopsy, belonging to the age group of 20-39 years of age, having no previous history or family history of any cardiac disease or Diabetes Mellitus. Tissues of coronary arteries were collected from the proximal part of the LAD, as it has the highest propensity to develop CAD and were studied histo-pathologically and results graded according to the AHA criteria. Results: Out of the 37 cases belonging to the age group of 30-39 years, 7(18.9%) cases have grade I-III change and 30(81.1%) cases have grade IV-VI changes [χ2 (5) = 30.65 p = 0.000]. Thus, age and CAD changes are positively correlated. Conclusion: The data obtained may form a baseline for the forthcoming studies, especially if done on a multi-centric basis.
