Impact electrochemical analysis of soft bio-particles: A mini review

Abstract

The measurement of single soft bio-particles has been regarded as one of the “holy grails” in the field of analytical chemistry. As a frontier of electrochemical analytical tool, single-particle impact electrochemistry (SPIE) allows in situ detection and counting of a variety of soft bio-particles, e.g., liposomes, viruses, bacteria and cells in a simple and fast way. In this review article, we summarize the representative work of SPIE based soft bio-particle analysis, categorized by the detection principle, namely diffusion blocking, redox labeling or/and mediating and direct electrolysis. A discussion of further considerations worth investigating in the future is followed.

Keywords

• Single particle impact electrochemistry
• Soft bio-particle
• Diffusion blocking
• Redox labeling
• Redox mediating
• Direct electrolysis