Preparing better: Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV) therapeutics trials lessons learned: A call to the future

Stacey J. Adam; Timothy G. Buchman; Judith S. Currier; Ruxandra Draghia-Akli; Josh P. Fessel; Elizabeth S. Higgs; Eric A. Hughes; Lisa LaVange; Joseph P. Menetski; Sarah W. Read; Yves Rosenberg; Randall Tressler; ACTIV Therapeutics-Clinical Working Group

doi:10.1017/cts.2024.178

Journal of Clinical and Translational Science (Jan 2024)

Preparing better: Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV) therapeutics trials lessons learned: A call to the future

Stacey J. Adam,
Timothy G. Buchman,
Judith S. Currier,
Ruxandra Draghia-Akli,
Josh P. Fessel,
Elizabeth S. Higgs,
Eric A. Hughes,
Lisa LaVange,
Joseph P. Menetski,
Sarah W. Read,
Yves Rosenberg,
Randall Tressler,
ACTIV Therapeutics-Clinical Working Group

Affiliations

Stacey J. Adam: ORCiD; Foundation for the National Institutes of Health, North Bethesda, MD, USA
Timothy G. Buchman: Critical Care Center, Emory University School of Medicine, Atlanta, GA, USA
Judith S. Currier: Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
Ruxandra Draghia-Akli: The Janssen Pharmaceutical Companies of Johnson & Johnson, Titusville, NJ, USA
Josh P. Fessel: National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA
Elizabeth S. Higgs: National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA
Eric A. Hughes: Teva Pharmaceuticals, Parsippany, NJ, USA
Lisa LaVange: Biostatistics, Gillings School of Global Public Health at the University of North Carolina at Chapel Hill, NC, USA
Joseph P. Menetski: Foundation for the National Institutes of Health, North Bethesda, MD, USA
Sarah W. Read: ORCiD; National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA
Yves Rosenberg: National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
Randall Tressler: National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA
ACTIV Therapeutics-Clinical Working Group

DOI: https://doi.org/10.1017/cts.2024.178
Journal volume & issue: Vol. 8

Abstract

Read online

The Accelerating COVID-19 Therapeutic Interventions and Vaccines Therapeutic-Clinical Working Group members gathered critical recommendations in follow-up to lessons learned manuscripts released earlier in the COVID-19 pandemic. Lessons around agent prioritization, preclinical therapeutics testing, master protocol design and implementation, drug manufacturing and supply, data sharing, and public–private partnership value are shared to inform responses to future pandemics.

Published in Journal of Clinical and Translational Science

ISSN: 2059-8661 (Online)
Publisher: Cambridge University Press
Country of publisher: United Kingdom
LCC subjects: Medicine
Website: https://www.cambridge.org/core/journals/journal-of-clinical-and-translational-science

About the journal

Abstract

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