Targeting Long Non-Coding RNAs in Hepatocellular Carcinoma: Progress and Prospects

Xinrong Lin; Xiaosong Xiang; Bing Feng; Hao Zhou; Ting Wang; Xiaoyuan Chu; Rui Wang

doi:10.3389/fonc.2021.670838

Frontiers in Oncology (Jun 2021)

Targeting Long Non-Coding RNAs in Hepatocellular Carcinoma: Progress and Prospects

Xinrong Lin,
Xiaosong Xiang,
Bing Feng,
Hao Zhou,
Ting Wang,
Xiaoyuan Chu,
Rui Wang

Affiliations

Xinrong Lin: Department of Medical Oncology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, China
Xiaosong Xiang: Affiliated Jingling Hospital Research Institution of General Surgery, School of Medicine, Nanjing University, Nanjing, China
Bing Feng: Department of Medical Oncology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, China
Hao Zhou: Department of Medical Oncology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, China
Ting Wang: Department of Medical Oncology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, China
Xiaoyuan Chu: Department of Medical Oncology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, China
Rui Wang: Department of Medical Oncology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, China

DOI: https://doi.org/10.3389/fonc.2021.670838
Journal volume & issue: Vol. 11

Abstract

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Hepatocellular carcinoma is the fifth-ranked cancer worldwide with a relatively low five-year survival rate. Long non-coding RNAs are a group of RNAs with remarkable aberrant expression which could act on multiple bioprocesses and ultimately impact upon tumor proliferation, invasion, migration, metastasis, apoptosis, and therapy resistance in cancer cells including hepatocellular carcinoma cells. In recent years, long non-coding RNAs have been reported to be indispensable targets in clinical target therapy to stop the growth of cancer and prolong the lifespan of patients with hepatocellular carcinoma. In this review, we enumerate the signaling pathways and life activities affected by long non-coding RNAs in hepatocellular carcinoma cells to illustrate the role of long non-coding RNAs in the development and therapy resistance of hepatocellular carcinoma.

Published in Frontiers in Oncology

ISSN: 2234-943X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.frontiersin.org/journals/oncology/

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