A <i>Drosophila</i> RNAi screen reveals conserved glioblastoma-related adhesion genes that regulate collective cell migration

Abstract

AbstractMigrating cell collectives are key to embryonic development but also contribute to invasion and metastasis of a variety of cancers. Cell collectives can invade deep into tissues, leading to tumor progression and resistance to therapies. Collective cell invasion is also observed in the lethal brain tumor glioblastoma (GBM), which infiltrates the surrounding brain parenchyma leading to tumor growth and poor patient outcomes. DrosophilaDrosophila