Microfluidic Flow Promotes a Steatotic Phenotype in Induced Pluripotent Stem Cell–Derived Hepatocytes that is Influenced by Disease State of the Donor

• Ekta Minocha,
• Linan Jiang,
• Ashwani Kumar Gupta,
• Richard M. Green,
• Yitshak Zohar,
• Jason A. Wertheim

Affiliations

Ekta Minocha

Department of Surgery, University of Arizona College of Medicine, Tucson, Arizona; Surgery Service, Southern Arizona VA Health Care System, Tucson, Arizona

Linan Jiang

Department of Aerospace and Mechanical Engineering, University of Arizona, Tucson, Arizona

Ashwani Kumar Gupta

Department of Surgery, University of Arizona College of Medicine, Tucson, Arizona; Surgery Service, Southern Arizona VA Health Care System, Tucson, Arizona

Richard M. Green

Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois

Yitshak Zohar

Department of Aerospace and Mechanical Engineering, University of Arizona, Tucson, Arizona; Yitshak Zohar, PhD, Aerospace and Mechanical Engineering, University of Arizona, Rm. N737, Tucson, Arizona 85721.

Jason A. Wertheim

Department of Surgery, University of Arizona College of Medicine, Tucson, Arizona; Department of Biomedical Engineering, University of Arizona, Tucson, Arizona; Surgery Service, Southern Arizona VA Health Care System, Tucson, Arizona; Correspondence: Address correspondence to: Jason A. Wertheim, MD, PhD, FACS, University of Arizona, College of Medicine, 1501 N. Campbell Ave., P.O. Box 245017, Tucson, Arizona 85724.