Endothelial dysfunction in development of cerebrovascular disorders in patients with diabetes mellitus

Abstract

Endothelial dysfunction and aberrations of haemostasis play an important part in development of cerebrovascular disorders in patientswith diabetes mellitus. Such factors as hyper- and hypoglycemia, hyperinsulinism, insulin resistance and excessive weight affect progressionof microcirculation deficiency and cerebral ischemia. Transcranial Doppler ultrasound examination is useful as a noninvasivemethod of hemodynamic assessment.

Keywords

• diabetes mellitus
• cerebral angiopathy
• endothelial dysfunction