Nature Communications (Jul 2020)

Immunoprophylactic and immunotherapeutic control of hormone receptor-positive breast cancer

  • Aitziber Buqué,
  • Norma Bloy,
  • Maria Perez-Lanzón,
  • Kristina Iribarren,
  • Juliette Humeau,
  • Jonathan G. Pol,
  • Sarah Levesque,
  • Laura Mondragon,
  • Takahiro Yamazaki,
  • Ai Sato,
  • Fernando Aranda,
  • Sylvère Durand,
  • Alexandre Boissonnas,
  • Jitka Fucikova,
  • Laura Senovilla,
  • David Enot,
  • Michal Hensler,
  • Margerie Kremer,
  • Gautier Stoll,
  • Yang Hu,
  • Chiara Massa,
  • Silvia C. Formenti,
  • Barbara Seliger,
  • Olivier Elemento,
  • Radek Spisek,
  • Fabrice André,
  • Laurence Zitvogel,
  • Suzette Delaloge,
  • Guido Kroemer,
  • Lorenzo Galluzzi

DOI
https://doi.org/10.1038/s41467-020-17644-0
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 18

Abstract

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Current preclinical models to investigate human HR + breast cancer progression and response to immunotherapy in vivo are limited. Here, the authors demonstrate that mammary tumours driven by a synthetic progestin combined with an oral carcinogen recapitulate several immunobiological features of human HR + breast cancers.