Mechanism of synergistic actin filament pointed end depolymerization by cyclase-associated protein and cofilin

Tommi Kotila; Hugo Wioland; Giray Enkavi; Konstantin Kogan; Ilpo Vattulainen; Antoine Jégou; Guillaume Romet-Lemonne; Pekka Lappalainen

doi:10.1038/s41467-019-13213-2

Nature Communications (Nov 2019)

Mechanism of synergistic actin filament pointed end depolymerization by cyclase-associated protein and cofilin

Tommi Kotila,
Hugo Wioland,
Giray Enkavi,
Konstantin Kogan,
Ilpo Vattulainen,
Antoine Jégou,
Guillaume Romet-Lemonne,
Pekka Lappalainen

Affiliations

Tommi Kotila: HiLIFE Institute of Biotechnology, University of Helsinki
Hugo Wioland: Université de Paris, CNRS, Institut Jacques Monod
Giray Enkavi: Department of Physics, University of Helsinki
Konstantin Kogan: HiLIFE Institute of Biotechnology, University of Helsinki
Ilpo Vattulainen: Department of Physics, University of Helsinki
Antoine Jégou: Université de Paris, CNRS, Institut Jacques Monod
Guillaume Romet-Lemonne: Université de Paris, CNRS, Institut Jacques Monod
Pekka Lappalainen: HiLIFE Institute of Biotechnology, University of Helsinki

DOI: https://doi.org/10.1038/s41467-019-13213-2
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

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The cofilin family proteins are actin disassembly factors but the disassembly mechanism is poorly understood. Here authors show that cyclase-associated-protein (CAP) works in synergy with cofilin to accelerate actin filament depolymerization by nearly 100-fold and reveal how CAP destabilizes the interface between terminal actin subunits.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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