Nature Communications (Apr 2019)
A small molecule promotes cartilage extracellular matrix generation and inhibits osteoarthritis development
- Yuanyuan Shi,
- Xiaoqing Hu,
- Jin Cheng,
- Xin Zhang,
- Fengyuan Zhao,
- Weili Shi,
- Bo Ren,
- Huilei Yu,
- Peng Yang,
- Zong Li,
- Qiang Liu,
- Zhenlong Liu,
- Xiaoning Duan,
- Xin Fu,
- Jiying Zhang,
- Jianquan Wang,
- Yingfang Ao
Affiliations
- Yuanyuan Shi
- Institute of Sports Medicine, Beijing Key Laboratory of Sports Injuries, Peking University Third Hospital
- Xiaoqing Hu
- Institute of Sports Medicine, Beijing Key Laboratory of Sports Injuries, Peking University Third Hospital
- Jin Cheng
- Institute of Sports Medicine, Beijing Key Laboratory of Sports Injuries, Peking University Third Hospital
- Xin Zhang
- Institute of Sports Medicine, Beijing Key Laboratory of Sports Injuries, Peking University Third Hospital
- Fengyuan Zhao
- Institute of Sports Medicine, Beijing Key Laboratory of Sports Injuries, Peking University Third Hospital
- Weili Shi
- Institute of Sports Medicine, Beijing Key Laboratory of Sports Injuries, Peking University Third Hospital
- Bo Ren
- Institute of Sports Medicine, Beijing Key Laboratory of Sports Injuries, Peking University Third Hospital
- Huilei Yu
- Institute of Sports Medicine, Beijing Key Laboratory of Sports Injuries, Peking University Third Hospital
- Peng Yang
- Institute of Sports Medicine, Beijing Key Laboratory of Sports Injuries, Peking University Third Hospital
- Zong Li
- Institute of Sports Medicine, Beijing Key Laboratory of Sports Injuries, Peking University Third Hospital
- Qiang Liu
- Institute of Sports Medicine, Beijing Key Laboratory of Sports Injuries, Peking University Third Hospital
- Zhenlong Liu
- Institute of Sports Medicine, Beijing Key Laboratory of Sports Injuries, Peking University Third Hospital
- Xiaoning Duan
- Institute of Sports Medicine, Beijing Key Laboratory of Sports Injuries, Peking University Third Hospital
- Xin Fu
- Institute of Sports Medicine, Beijing Key Laboratory of Sports Injuries, Peking University Third Hospital
- Jiying Zhang
- Institute of Sports Medicine, Beijing Key Laboratory of Sports Injuries, Peking University Third Hospital
- Jianquan Wang
- Institute of Sports Medicine, Beijing Key Laboratory of Sports Injuries, Peking University Third Hospital
- Yingfang Ao
- Institute of Sports Medicine, Beijing Key Laboratory of Sports Injuries, Peking University Third Hospital
- DOI
- https://doi.org/10.1038/s41467-019-09839-x
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 14
Abstract
Loss of cartilage tissue is a hallmark of osteoarthritis. Here the authors show that BNTA, a small molecule identified in a chemical screen, promotes ECM generation in human osteoarthritic chondrocytes and cartilage explants, and suppresses pathology in a rat model of osteoarthritis.
