Fasting blood glucose level in oral squamous cell carcinoma: Analysis of 205 cases by histopathology and serological detection

Abstract

Objective: The present study explored the correlation between FBG level with clinicopathological features and prognosis, a total of 205 OSCC patients were included retrospectively. Materials and methods: 205 patients who were admitted to the Department of Oral and Maxillofacial Oncology Surgery from January 2008 to December 2019, were enrolled. ROC curve analysis was used to obtain the optimal cutoff value for FBG; The Cox proportional hazard regression model for the risk factors affecting prognosis. Results: Cox proportional regression models univariate analysis showed that age, treatment, neck lymphatic dissection, surgical margin, FBG, BMI were positive predictors, while primary tumor size, differentiation, tumor recurrence, drinking were negative predictors; on multivariable Cox regression analysis, tumor recurrence, BMI, FBG, surgical margin and alcohol consumption were independently and significantly related to the outcome of OSCC. Conclusions: The FBG is an independent prognostic factor for patients with OSCC. To improve the overall survival of patients with OSCC, comprehensive treatment based on radical surgery should be considered as the major treatment modalities.

Keywords

• Oral squamous cell carcinoma
• Prognosis
• Fasting blood glucose level