Synthesis, Characterization and Biological Activities of Biopolymeric Schiff Bases Prepared with Chitosan and Salicylaldehydes and Their Pd(II) and Pt(II) Complexes
Hellen Franciane Gonçalves Barbosa,
Maha Attjioui,
Ana Paula Garcia Ferreira,
Edward Ralph Dockal,
Nour Eddine El Gueddari,
Bruno M. Moerschbacher,
Éder Tadeu Gomes Cavalheiro
Affiliations
Hellen Franciane Gonçalves Barbosa
Instituto de Química de São Carlos, Universidade de São Paulo, Av. Trabalhador São Carlense, 400, São Carlos 13566-590, SP, Brazil
Maha Attjioui
Institute of Plant Biology and Biotechnology (IBBP), Westfälische Wilhelms-Universität Münster, Schlossplatz 8, 48143 Münster, Germany
Ana Paula Garcia Ferreira
Instituto de Química de São Carlos, Universidade de São Paulo, Av. Trabalhador São Carlense, 400, São Carlos 13566-590, SP, Brazil
Edward Ralph Dockal
Departmento de Química, Universidade Federal de São Carlos, Via Washington Luis, Km 235, São Carlos 13560-900, SP, Brazil
Nour Eddine El Gueddari
Institute of Plant Biology and Biotechnology (IBBP), Westfälische Wilhelms-Universität Münster, Schlossplatz 8, 48143 Münster, Germany
Bruno M. Moerschbacher
Institute of Plant Biology and Biotechnology (IBBP), Westfälische Wilhelms-Universität Münster, Schlossplatz 8, 48143 Münster, Germany
Éder Tadeu Gomes Cavalheiro
Institute of Plant Biology and Biotechnology (IBBP), Westfälische Wilhelms-Universität Münster, Schlossplatz 8, 48143 Münster, Germany
In an attempt to enhance chitosan biological activities, biopolymeric Schiff bases of chitosan and different salicylaldehydes and their palladium(II) and platinum(II) complexes were synthesized and tested. The chemical structures of these derivatives were characterized using 1H-NMR, FTIR spectroscopy and XPRD. Thermal analysis was done through TGA/DTG-DTA. Electronic absorption spectra and surface morphologies were analyzed by SEM-EDAX. Chitosan and its derivatives were evaluated for their in vitro antimicrobial activity against two common bacterial and fungal plant pathogens Pseudomonas syringae pv. tomato and Fusarium graminearum, respectively, and for their antitumor activity against a human breast cancer cell line (MCF-7). It was found that, compared to the nonmodified chitosan, chitosan modified with Schiff bases and their complexes was highly toxic against the MCF-7 cell line and had antibacterial effects against P. syringea. However, the modified chitosan derivatives had less pronounced antifungal effects against F. graminearum compared to the nonmodified chitosan, suggesting different modes of action.
