Mild-temperature photothermal assisted CuSi nanowires for promoting infected wound healing

Yanping Feng; Yanping Feng; Yanping Feng; Mingzhen Wu; Mingzhen Wu; Haidong Zhang; He Xu; Huili Li; Huili Li; Dongmin Chen; Dongmin Chen; Hongyi Jiang; Jiang Chang; Jiang Chang; Jiang Chang; Zhihong Dong; Chen Yang; Chen Yang

doi:10.3389/fbioe.2023.1158007

Frontiers in Bioengineering and Biotechnology (Mar 2023)

Mild-temperature photothermal assisted CuSi nanowires for promoting infected wound healing

Yanping Feng,
Yanping Feng,
Yanping Feng,
Mingzhen Wu,
Mingzhen Wu,
Haidong Zhang,
He Xu,
Huili Li,
Huili Li,
Dongmin Chen,
Dongmin Chen,
Hongyi Jiang,
Jiang Chang,
Jiang Chang,
Jiang Chang,
Zhihong Dong,
Chen Yang,
Chen Yang

Affiliations

Yanping Feng: College of Mechanical Engineering, Chengdu University, Chengdu, Sichuan, China
Yanping Feng: Joint Centre of Translational Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
Yanping Feng: Zhejiang Engineering Research Center for Tissue Repair Materials, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, China
Mingzhen Wu: College of Chemistry and Materials Sciences, Shanghai Normal University, Shanghai, China
Mingzhen Wu: Zhejiang Engineering Research Center for Tissue Repair Materials, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, China
Haidong Zhang: Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing, China
He Xu: College of Chemistry and Materials Sciences, Shanghai Normal University, Shanghai, China
Huili Li: Joint Centre of Translational Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
Huili Li: Zhejiang Engineering Research Center for Tissue Repair Materials, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, China
Dongmin Chen: Joint Centre of Translational Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
Dongmin Chen: Zhejiang Engineering Research Center for Tissue Repair Materials, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, China
Hongyi Jiang: Zhejiang Engineering Research Center for Tissue Repair Materials, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, China
Jiang Chang: Joint Centre of Translational Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
Jiang Chang: Zhejiang Engineering Research Center for Tissue Repair Materials, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, China
Jiang Chang: College of Chemistry and Materials Sciences, Shanghai Normal University, Shanghai, China
Zhihong Dong: College of Mechanical Engineering, Chengdu University, Chengdu, Sichuan, China
Chen Yang: Joint Centre of Translational Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
Chen Yang: Zhejiang Engineering Research Center for Tissue Repair Materials, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, China

DOI: https://doi.org/10.3389/fbioe.2023.1158007
Journal volume & issue: Vol. 11

Abstract

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In clinical practice, the utilization of antibiotics is still the main approach for the treatment of wound contamination, which lacks the ability to accelerate wound healing and arises the global concern of antimicrobial resistance. Plenty of alternative methods have been explored in recent years due to the fast development of material science. Here, CuO/SiO2 nanowires (CuSi NWs) with good near-infrared (NIR) photothermal conversion ability are synthesized by a one-step hydrothermal method. The as-prepared CuSi NWs possess excellent antibacterial ability against both Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), which could be enhanced by the assistance of mild photothermal therapy (PTT). Moreover, CuSi NWs at suitable concentrations can promote proliferation, migration, and angiogenic gene expression of human umbilical vein endothelial cells (HUVECs), exhibiting a remarkable pro-vascularization ability. The in vivo mouse infect model further proves that the CuSi NWs might be a good candidate for the treatment of infected wounds as the high antibacterial efficiency and accelerated wound healing is obtained.

Published in Frontiers in Bioengineering and Biotechnology

ISSN: 2296-4185 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Technology: Chemical technology: Biotechnology
Website: http://www.frontiersin.org/bioengineering_and_biotechnology

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