Progress in the study of signal transduction pathways related to the pathogenesis of glaucoma

Meng-Han Xu; Tao Liu

doi:10.3980/j.issn.1672-5123.2021.6.17

Guoji Yanke Zazhi (Jun 2021)

Progress in the study of signal transduction pathways related to the pathogenesis of glaucoma

Meng-Han Xu,
Tao Liu

Affiliations

Meng-Han Xu: Xi'an Medical University, Xi'an 710021, Shaanxi Province, China
Tao Liu: Department of Ophthalmology, Hanzhong 3201 Hospital, Hanzhong 723200, Shaanxi Province, China

DOI: https://doi.org/10.3980/j.issn.1672-5123.2021.6.17
Journal volume & issue: Vol. 21, no. 6
pp. 1021 – 1024

Abstract

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Glaucoma is the leading cause of irreversible vision loss in the world. Drugs and surgery can be used to control intraocular pressure, however, they can't reverse the apoptosis of retinal ganglion cells effectively. With the development of genetics and molecular biology, a large amount of research on the pathogenesis of glaucoma has been conducted. This review discusses the potential role of Rho/ROCK, TGF-β/Smad, PI3K/Akt, Nrf2/Keap1/ARE and BDNF/TrkB signaling pathways in the pathogenesis of glaucoma, and expects to provide new ideas and methods for the treatment of glaucoma.

Published in Guoji Yanke Zazhi

ISSN: 1672-5123 (Print)
Publisher: Press of International Journal of Ophthalmology (IJO PRESS)
Country of publisher: China
LCC subjects: Medicine: Ophthalmology
Website: http://ies.ijo.cn/

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Abstract

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