Sonogenetic control of mammalian cells using exogenous Transient Receptor Potential A1 channels

Marc Duque; Corinne A. Lee-Kubli; Yusuf Tufail; Uri Magaram; Janki Patel; Ahana Chakraborty; Jose Mendoza Lopez; Eric Edsinger; Aditya Vasan; Rani Shiao; Connor Weiss; James Friend; Sreekanth H. Chalasani

doi:10.1038/s41467-022-28205-y

Nature Communications (Feb 2022)

Sonogenetic control of mammalian cells using exogenous Transient Receptor Potential A1 channels

Marc Duque,
Corinne A. Lee-Kubli,
Yusuf Tufail,
Uri Magaram,
Janki Patel,
Ahana Chakraborty,
Jose Mendoza Lopez,
Eric Edsinger,
Aditya Vasan,
Rani Shiao,
Connor Weiss,
James Friend,
Sreekanth H. Chalasani

Affiliations

Marc Duque: Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies
Corinne A. Lee-Kubli: Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies
Yusuf Tufail: Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies
Uri Magaram: Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies
Janki Patel: Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies
Ahana Chakraborty: Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies
Jose Mendoza Lopez: Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies
Eric Edsinger: Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies
Aditya Vasan: Medically Advanced Devices Laboratory, Department of Mechanical and Aerospace Engineering, Jacobs School of Engineering, University of California San Diego
Rani Shiao: Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies
Connor Weiss: Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies
James Friend: Medically Advanced Devices Laboratory, Department of Mechanical and Aerospace Engineering, Jacobs School of Engineering, University of California San Diego
Sreekanth H. Chalasani: Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies

DOI: https://doi.org/10.1038/s41467-022-28205-y
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 17

Abstract

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Ultrasound can be used to non-invasively control neuronal functions. Here the authors report the use of human Transient receptor potential ankyrin 1 (hsTRPA1) to achieve ultrasound sensitivity in mammalian cells, and show that it can be used to manipulate neurons in the mammalian brain.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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