Nature Communications (Jun 2019)

Minimal exposure of lipid II cycle intermediates triggers cell wall antibiotic resistance

  • Hannah Piepenbreier,
  • Angelika Diehl,
  • Georg Fritz

DOI
https://doi.org/10.1038/s41467-019-10673-4
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 13

Abstract

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Antibiotics targeting cell wall synthesis display an unexplained gap between in vivo efficacy and in vitro binding affinity for their target. Here, Piepenbreier et al. develop a model for bacterial cell wall biosynthesis, show how it is affected by antibiotics, and use it to predict in vivo efficacy of antibiotics.