The discovery of AVIL as a bona fide oncogene in glioblastoma

Abstract

Our work in rhabdomyosarcoma led us to the discovery of a novel oncogene, Advillin (AVIL) in glioblastoma. Multiple lines of evidence support that AVIL is an Achilles heel of glioblastoma, with its specific targeting potentially an effective treatment approach for the disease. A new signaling axis was also established.

Keywords

• avil
• glioblastoma
• rhabdomyosarcoma
• oncogene addiction