Crystal structure and cellular functions of uPAR dimer

Shujuan Yu; Yaqun Sui; Jiawei Wang; Yongdong Li; Hanlin Li; Yingping Cao; Liqing Chen; Longguang Jiang; Cai Yuan; Mingdong Huang

doi:10.1038/s41467-022-29344-y

Nature Communications (Mar 2022)

Crystal structure and cellular functions of uPAR dimer

Shujuan Yu,
Yaqun Sui,
Jiawei Wang,
Yongdong Li,
Hanlin Li,
Yingping Cao,
Liqing Chen,
Longguang Jiang,
Cai Yuan,
Mingdong Huang

Affiliations

Shujuan Yu: College of Chemistry, Fuzhou University, Fuzhou
Yaqun Sui: College of Chemistry, Fuzhou University, Fuzhou
Jiawei Wang: Tsinghua University
Yongdong Li: College of Chemistry, Fuzhou University, Fuzhou
Hanlin Li: College of Chemistry, Fuzhou University, Fuzhou
Yingping Cao: Department of Clinical Laboratory, Fujian Medical University Union Hospital
Liqing Chen: School of Molecular Sciences, Arizona State University
Longguang Jiang: College of Chemistry, Fuzhou University, Fuzhou
Cai Yuan: College of Biological Science and Engineering, Fuzhou University
Mingdong Huang: College of Chemistry, Fuzhou University, Fuzhou

DOI: https://doi.org/10.1038/s41467-022-29344-y
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 11

Abstract

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The structural basis for urokinase-type plasminogen activator receptor (uPAR) dimerization is not understood. Here, the authors solve the crystal structure of soluble uPAR dimers, identifying substantial structural changes compared to the monomer.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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