Nature Communications (Jan 2023)

Differential sensing with arrays of de novo designed peptide assemblies

  • William M. Dawson,
  • Kathryn L. Shelley,
  • Jordan M. Fletcher,
  • D. Arne Scott,
  • Lucia Lombardi,
  • Guto G. Rhys,
  • Tania J. LaGambina,
  • Ulrike Obst,
  • Antony J. Burton,
  • Jessica A. Cross,
  • George Davies,
  • Freddie J. O. Martin,
  • Francis J. Wiseman,
  • R. Leo Brady,
  • David Tew,
  • Christopher W. Wood,
  • Derek N. Woolfson

DOI
https://doi.org/10.1038/s41467-023-36024-y
Journal volume & issue
Vol. 14, no. 1
pp. 1 – 12

Abstract

Read online

Differential sensing aims to mimic senses such as taste and smell through the use of synthetic receptors. Here, the authors show that arrays of de novo designed peptide assemblies can be used as sensor components to distinguish various analytes and complex mixtures.