Nature Communications (Jan 2023)
Differential sensing with arrays of de novo designed peptide assemblies
- William M. Dawson,
- Kathryn L. Shelley,
- Jordan M. Fletcher,
- D. Arne Scott,
- Lucia Lombardi,
- Guto G. Rhys,
- Tania J. LaGambina,
- Ulrike Obst,
- Antony J. Burton,
- Jessica A. Cross,
- George Davies,
- Freddie J. O. Martin,
- Francis J. Wiseman,
- R. Leo Brady,
- David Tew,
- Christopher W. Wood,
- Derek N. Woolfson
Affiliations
- William M. Dawson
- School of Chemistry, University of Bristol, Cantock’s Close
- Kathryn L. Shelley
- School of Chemistry, University of Bristol, Cantock’s Close
- Jordan M. Fletcher
- School of Chemistry, University of Bristol, Cantock’s Close
- D. Arne Scott
- School of Chemistry, University of Bristol, Cantock’s Close
- Lucia Lombardi
- School of Chemistry, University of Bristol, Cantock’s Close
- Guto G. Rhys
- School of Chemistry, University of Bristol, Cantock’s Close
- Tania J. LaGambina
- Rosa Biotech, Science Creates St Philips
- Ulrike Obst
- Rosa Biotech, Science Creates St Philips
- Antony J. Burton
- School of Chemistry, University of Bristol, Cantock’s Close
- Jessica A. Cross
- School of Chemistry, University of Bristol, Cantock’s Close
- George Davies
- School of Chemistry, University of Bristol, Cantock’s Close
- Freddie J. O. Martin
- School of Chemistry, University of Bristol, Cantock’s Close
- Francis J. Wiseman
- School of Chemistry, University of Bristol, Cantock’s Close
- R. Leo Brady
- School of Biochemistry, University of Bristol, Medical Sciences Building, University Walk
- David Tew
- GlaxoSmithKline (GSK)
- Christopher W. Wood
- School of Chemistry, University of Bristol, Cantock’s Close
- Derek N. Woolfson
- School of Chemistry, University of Bristol, Cantock’s Close
- DOI
- https://doi.org/10.1038/s41467-023-36024-y
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 12
Abstract
Differential sensing aims to mimic senses such as taste and smell through the use of synthetic receptors. Here, the authors show that arrays of de novo designed peptide assemblies can be used as sensor components to distinguish various analytes and complex mixtures.
