Vaccines (Apr 2023)
Synergistic Effect between SARS-CoV-2 Wave and COVID-19 Vaccination on the Occurrence of Mild Symptoms in Healthcare Workers
- Valentin Imeshtari,
- Francesca Vezza,
- Vanessa India Barletta,
- Andrea Bongiovanni,
- Corrado Colaprico,
- David Shaholli,
- Eleonora Ricci,
- Giovanna Carluccio,
- Luca Moretti,
- Maria Vittoria Manai,
- Marta Chiappetta,
- Riccardo Paolini,
- Mattia Marte,
- Carlo Maria Previte,
- Lavinia Camilla Barone,
- Augusto Faticoni,
- Vittoria Cammalleri,
- Roberta Noemi Pocino,
- Filippo Picchioni,
- Shizuka Kibi,
- Gloria Deriu,
- Pasquale Serruto,
- Barbara Dorelli,
- Elena Mazzalai,
- Monica Giffi,
- Daniela Marotta,
- Mattia Manzi,
- Valentina Marasca,
- Rosario Andrea Cocchiara,
- Federica Ciccone,
- Patrizia Pasculli,
- Paola Massetti,
- Guido Antonelli,
- Claudio Maria Mastroianni,
- Giuseppe La Torre
Affiliations
- Valentin Imeshtari
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- Francesca Vezza
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- Vanessa India Barletta
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- Andrea Bongiovanni
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- Corrado Colaprico
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- David Shaholli
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- Eleonora Ricci
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- Giovanna Carluccio
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- Luca Moretti
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- Maria Vittoria Manai
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- Marta Chiappetta
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- Riccardo Paolini
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- Mattia Marte
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- Carlo Maria Previte
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- Lavinia Camilla Barone
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- Augusto Faticoni
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- Vittoria Cammalleri
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- Roberta Noemi Pocino
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- Filippo Picchioni
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- Shizuka Kibi
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- Gloria Deriu
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- Pasquale Serruto
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- Barbara Dorelli
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- Elena Mazzalai
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- Monica Giffi
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- Daniela Marotta
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- Mattia Manzi
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- Valentina Marasca
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- Rosario Andrea Cocchiara
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- Federica Ciccone
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- Patrizia Pasculli
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- Paola Massetti
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- Guido Antonelli
- Laboratory of Microbiology and Virology, Department of Molecular Medicine, Sapienza University of Rome, 00185 Rome, Italy
- Claudio Maria Mastroianni
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- Giuseppe La Torre
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- DOI
- https://doi.org/10.3390/vaccines11050882
- Journal volume & issue
-
Vol. 11,
no. 5
p. 882
Abstract
Background: Since the beginning of the pandemic, five variants of epidemiological interest have been identified, each of them with its pattern of symptomology and disease severity. The aim of this study is to analyze the role of vaccination status in modulating the pattern of symptomatology associated with COVID-19 infection during four waves. Methods: Data from the surveillance activity of healthcare workers were used to carry out descriptive analysis, association analyses and multivariable analysis. A synergism analysis between vaccination status and symptomatology during the waves was performed. Results: Females were found at a higher risk of developing symptoms. Four SARS-CoV-2 waves were identified. Pharyngitis and rhinitis were more frequent during the fourth wave and among vaccinated subjects while cough, fever, flu syndrome, headache, anosmia, ageusia, arthralgia/arthritis and myalgia were more frequent during the first three waves and among unvaccinated subjects. A correlation was found between vaccination and the different waves in terms of developing pharyngitis and rhinitis. Conclusion: Vaccination status and viruses’ mutations had a synergic effect in the mitigation of the symptomatology caused by SARS-CoV-2 in healthcare workers.
Keywords
