Surveillance of COVID-19 vaccines: A comprehensive analysis of the first immunization drive in Ecuador
Andrea Orellana-Manzano,
Andrea C. Garcia-Angulo,
Fernanda B. Cordeiro,
Diana Carvajal-Aldaz,
Elizabeth Centeno,
María J. Vizcaíno,
Sebastián Poveda,
Merly Garcia,
Carmen Matías-De la Cruz,
Derly Andrade-Molina,
Mariuxi Mirabá,
Saurabh Mehta,
Washington B. Cárdenas
Affiliations
Andrea Orellana-Manzano
Laboratorio Para Investigaciones Biomédicas, Facultad de Ciencias de la Vida, Escuela Superior Politécnica del Litoral (ESPOL), Guayaquil, Ecuador; Corresponding author.
Andrea C. Garcia-Angulo
Facultad de Ciencias Naturales y Matemáticas, Escuela Superior Politécnica del Litoral (ESPOL), Guayaquil, Ecuador
Fernanda B. Cordeiro
Laboratorio Para Investigaciones Biomédicas, Facultad de Ciencias de la Vida, Escuela Superior Politécnica del Litoral (ESPOL), Guayaquil, Ecuador
Diana Carvajal-Aldaz
Laboratorio Para Investigaciones Biomédicas, Facultad de Ciencias de la Vida, Escuela Superior Politécnica del Litoral (ESPOL), Guayaquil, Ecuador
Elizabeth Centeno
Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA
María J. Vizcaíno
Laboratorio Para Investigaciones Biomédicas, Facultad de Ciencias de la Vida, Escuela Superior Politécnica del Litoral (ESPOL), Guayaquil, Ecuador
Sebastián Poveda
Facultad de Ciencias Naturales y Matemáticas, Escuela Superior Politécnica del Litoral (ESPOL), Guayaquil, Ecuador
Merly Garcia
Laboratorio Para Investigaciones Biomédicas, Facultad de Ciencias de la Vida, Escuela Superior Politécnica del Litoral (ESPOL), Guayaquil, Ecuador
Carmen Matías-De la Cruz
Laboratorio Para Investigaciones Biomédicas, Facultad de Ciencias de la Vida, Escuela Superior Politécnica del Litoral (ESPOL), Guayaquil, Ecuador
Derly Andrade-Molina
Omics Sciences Laboratory, Universidad Espíritu Santo, Faculty of Health Sciences, Samborondón, Ecuador
Mariuxi Mirabá
Laboratorio Para Investigaciones Biomédicas, Facultad de Ciencias de la Vida, Escuela Superior Politécnica del Litoral (ESPOL), Guayaquil, Ecuador
Saurabh Mehta
Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA
Washington B. Cárdenas
Laboratorio Para Investigaciones Biomédicas, Facultad de Ciencias de la Vida, Escuela Superior Politécnica del Litoral (ESPOL), Guayaquil, Ecuador
The initial phase of the COVID-19 vaccination in Ecuador occurred between April and November 2021. Initially, it focused on priority populations, including health professionals and other front-line workers. During this period, there was limited knowledge about the vaccine's adverse effects. A non-probability, observational study was conducted among university staff in Guayaquil, Ecuador, who received the AstraZeneca vaccine (n = 423) between April and November 2021. This study aimed to compare the acute adverse reactions by doses and to report the incidence of long-term adverse reactions within the AstraZeneca group. As a result, comparing acute adverse reactions between doses, the odds ratio for local pain, headache, muscle pain, fever, and chills are statistically higher after the first dose than the second dose. Survival curves indicated these symptoms appeared mainly within the first 6 h post-vaccination. This is the first pharmacovigilance study from Ecuador that analyzes survival probabilities for the AstraZeneca vaccine's adverse effects.
