Nature Communications (Jan 2021)

ZNF143 mediates CTCF-bound promoter–enhancer loops required for murine hematopoietic stem and progenitor cell function

  • Qiling Zhou,
  • Miao Yu,
  • Roberto Tirado-Magallanes,
  • Bin Li,
  • Lingshi Kong,
  • Mingrui Guo,
  • Zi Hui Tan,
  • Sanghoon Lee,
  • Li Chai,
  • Akihiko Numata,
  • Touati Benoukraf,
  • Melissa Jane Fullwood,
  • Motomi Osato,
  • Bing Ren,
  • Daniel G. Tenen

DOI
https://doi.org/10.1038/s41467-020-20282-1
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 12

Abstract

Read online

CTCF mediates DNA–DNA interactions by forming dimers that directly bind to both sides of the DNA. Here the authors reveal that a CTCF known associated zinc finger, ZNF143, mediates gene transcription through CTCF–DNA binding to maintain murine hematopoietic stem and progenitor cell integrity.