Nature Communications (Apr 2018)

TAK1 activation of alpha-TAT1 and microtubule hyperacetylation control AKT signaling and cell growth

  • Nirav Shah,
  • Sanjay Kumar,
  • Naveed Zaman,
  • Christopher C. Pan,
  • Jeffrey C. Bloodworth,
  • Wei Lei,
  • John M. Streicher,
  • Nadine Hempel,
  • Karthikeyan Mythreye,
  • Nam Y. Lee

DOI
https://doi.org/10.1038/s41467-018-04121-y
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 12

Abstract

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Acetylation of microtubules (MT) confers mechanical stability necessary for numerous cellular functions but its regulation is unclear. Here the authors show that the MT acetyltransferase αTAT1 is regulated by TGF-β-activated kinase 1 implicating TGF-β signaling in MT-related functions and disease.