Nature Communications (Feb 2023)
FGL2-targeting T cells exhibit antitumor effects on glioblastoma and recruit tumor-specific brain-resident memory T cells
- Qingnan Zhao,
- Jiemiao Hu,
- Lingyuan Kong,
- Shan Jiang,
- Xiangjun Tian,
- Jing Wang,
- Rintaro Hashizume,
- Zhiliang Jia,
- Natalie Wall Fowlkes,
- Jun Yan,
- Xueqing Xia,
- Sofia F. Yi,
- Long Hoang Dao,
- David Masopust,
- Amy B. Heimberger,
- Shulin Li
Affiliations
- Qingnan Zhao
- Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
- Jiemiao Hu
- Division of Pediatrics, The University of Texas MD Anderson Cancer Center
- Lingyuan Kong
- Division of Pediatrics, The University of Texas MD Anderson Cancer Center
- Shan Jiang
- Uaub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University Irving Medical Center
- Xiangjun Tian
- Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center
- Jing Wang
- Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center
- Rintaro Hashizume
- Department of Neurological Surgery, Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University
- Zhiliang Jia
- Division of Pediatrics, The University of Texas MD Anderson Cancer Center
- Natalie Wall Fowlkes
- Department of Veterinary Medicine & Surgery, The University of Texas MD Anderson Cancer Center
- Jun Yan
- Beijing Institute of Brain Disorders, Capital Medical University
- Xueqing Xia
- Division of Pediatrics, The University of Texas MD Anderson Cancer Center
- Sofia F. Yi
- Division of Pediatrics, The University of Texas MD Anderson Cancer Center
- Long Hoang Dao
- Division of Pediatrics, The University of Texas MD Anderson Cancer Center
- David Masopust
- Department of Microbiology, Center for Immunology, University of Minnesota
- Amy B. Heimberger
- Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center
- Shulin Li
- Division of Pediatrics, The University of Texas MD Anderson Cancer Center
- DOI
- https://doi.org/10.1038/s41467-023-36430-2
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 18
Abstract
Glioblastoma is an aggressive type of cancer with poor patient prognosis. Here, the authors show that T cells armed with an FGL2-specific scFV can induce antitumour responses mediated by tissue-resident memory T cells in the brain.
