Frontiers in Immunology (Mar 2024)
Decidual γδT cells of early human pregnancy produce angiogenic and immunomodulatory proteins while also possessing cytotoxic potential
- Jasper Nörenberg,
- Jasper Nörenberg,
- Jasper Nörenberg,
- Péter Vida,
- Isabell Bösmeier,
- Barbara Forró,
- Anna Nörenberg,
- Anna Nörenberg,
- Anna Nörenberg,
- Ágnes Buda,
- Diana Simon,
- Diana Simon,
- Szabina Erdő-Bonyár,
- Szabina Erdő-Bonyár,
- Pál Jáksó,
- Kálmán Kovács,
- Kálmán Kovács,
- Éva Mikó,
- Éva Mikó,
- Éva Mikó,
- Tímea Berki,
- Tímea Berki,
- Emese Mezősi,
- Emese Mezősi,
- Alíz Barakonyi,
- Alíz Barakonyi,
- Alíz Barakonyi
Affiliations
- Jasper Nörenberg
- Department of Medical Microbiology and Immunology, University of Pécs Medical School, Clinical Center, Pécs, Hungary
- Jasper Nörenberg
- National Laboratory on Human Reproduction, University of Pécs, Pécs, Hungary
- Jasper Nörenberg
- Department of Obstetrics and Gynaecology, University of Pécs Medical School, Clinical Center, Pécs, Hungary
- Péter Vida
- Department of Obstetrics and Gynaecology, University of Pécs Medical School, Clinical Center, Pécs, Hungary
- Isabell Bösmeier
- Department of Medical Microbiology and Immunology, University of Pécs Medical School, Clinical Center, Pécs, Hungary
- Barbara Forró
- Department of Pathology, University of Pécs Medical School, Clinical Center, Pécs, Hungary
- Anna Nörenberg
- National Laboratory on Human Reproduction, University of Pécs, Pécs, Hungary
- Anna Nörenberg
- Department of Obstetrics and Gynaecology, University of Pécs Medical School, Clinical Center, Pécs, Hungary
- Anna Nörenberg
- Janos Szentagothai Research Centre, University of Pécs, Pécs, Hungary
- Ágnes Buda
- Department of Obstetrics and Gynaecology, University of Pécs Medical School, Clinical Center, Pécs, Hungary
- Diana Simon
- National Laboratory on Human Reproduction, University of Pécs, Pécs, Hungary
- Diana Simon
- Department of Immunology and Biotechnology, University of Pécs Medical School, Clinical Center, Pécs, Hungary
- Szabina Erdő-Bonyár
- National Laboratory on Human Reproduction, University of Pécs, Pécs, Hungary
- Szabina Erdő-Bonyár
- Department of Immunology and Biotechnology, University of Pécs Medical School, Clinical Center, Pécs, Hungary
- Pál Jáksó
- Department of Pathology, University of Pécs Medical School, Clinical Center, Pécs, Hungary
- Kálmán Kovács
- National Laboratory on Human Reproduction, University of Pécs, Pécs, Hungary
- Kálmán Kovács
- Department of Obstetrics and Gynaecology, University of Pécs Medical School, Clinical Center, Pécs, Hungary
- Éva Mikó
- Department of Medical Microbiology and Immunology, University of Pécs Medical School, Clinical Center, Pécs, Hungary
- Éva Mikó
- National Laboratory on Human Reproduction, University of Pécs, Pécs, Hungary
- Éva Mikó
- Janos Szentagothai Research Centre, University of Pécs, Pécs, Hungary
- Tímea Berki
- National Laboratory on Human Reproduction, University of Pécs, Pécs, Hungary
- Tímea Berki
- Department of Immunology and Biotechnology, University of Pécs Medical School, Clinical Center, Pécs, Hungary
- Emese Mezősi
- National Laboratory on Human Reproduction, University of Pécs, Pécs, Hungary
- Emese Mezősi
- First Department of Internal Medicine, University of Pécs Medical School, Clinical Center, Pécs, Hungary
- Alíz Barakonyi
- Department of Medical Microbiology and Immunology, University of Pécs Medical School, Clinical Center, Pécs, Hungary
- Alíz Barakonyi
- National Laboratory on Human Reproduction, University of Pécs, Pécs, Hungary
- Alíz Barakonyi
- Janos Szentagothai Research Centre, University of Pécs, Pécs, Hungary
- DOI
- https://doi.org/10.3389/fimmu.2024.1382424
- Journal volume & issue
-
Vol. 15
Abstract
During pregnancy, the maternal immune system must allow and support the growth of the developing placenta while maintaining the integrity of the mother’s body. The trophoblast’s unique HLA signature is a key factor in this physiological process. This study focuses on decidual γδT cell populations and examines their expression of receptors that bind to non-classical HLA molecules, HLA-E and HLA-G. We demonstrate that decidual γδT cell subsets, including Vδ1, Vδ2, and double-negative (DN) Vδ1-/Vδ2- cells express HLA-specific regulatory receptors, such as NKG2C, NKG2A, ILT2, and KIR2DL4, each with varying dominance. Furthermore, decidual γδT cells produce cytokines (G-CSF, FGF2) and cytotoxic mediators (Granulysin, IFN-γ), suggesting functions in placental growth and pathogen defense. However, these processes seem to be controlled by factors other than trophoblast-derived non-classical HLA molecules. These findings indicate that decidual γδT cells have the potential to actively contribute to the maintenance of healthy human pregnancy.
Keywords
