Immuno (Sep 2023)

Monoclonal War: The Antibody Arsenal and Targets for Expanded Application

  • Eric H. Rosenn,
  • Mickael Benhaim,
  • Allison Siegel,
  • David A. Stein,
  • Joseph S. Leonard,
  • Erik Katcher,
  • Dania Halperin,
  • Zachary Mostel

DOI
https://doi.org/10.3390/immuno3030021
Journal volume & issue
Vol. 3, no. 3
pp. 346 – 357

Abstract

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Advancements in sequencing and screening technology have made monoclonal antibodies more accessible, cost-effective, and precise. These drugs effectively target pathogens and cancer cells and even regulate metabolic pathways by focusing on specific intermediates. Monoclonal antibodies play a key role in mitigating a rise in occupation-related cancers, neurodegenerative disorders, and multidrug-resistant organisms. Here, we review the origins, mechanisms, and applications of this important drug class and explore future avenues for research.

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