Supplementing a specific synbiotic suppressed the incidence of AOM/DSS-induced colorectal cancer in mice
Huixia Wu,
Zhengchun Wu,
Yilan Qiu,
Fangjian Zhao,
Minjing Liao,
Zhihong Zhong,
Jian Chen,
Yiliang Zeng,
Rushi Liu
Affiliations
Huixia Wu
Department of Medical Laboratory, School of Medicine, Hunan Normal University, Changsha 410013, China
Zhengchun Wu
Department of Hepatobiliary and Intestinal Surgery, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, China
Yilan Qiu
School of Life Science, Hunan Normal University, Changsha 410018, China; Changsha Tianan Biotechnology Co., Ltd., Changsha 410018, China
Fangjian Zhao
Medical Laboratory, The First Affiliated Hospital of Hunan Normal University, Changsha 410018, China
Minjing Liao
Department of Medical Laboratory, School of Medicine, Hunan Normal University, Changsha 410013, China
Zhihong Zhong
Department of Medical Laboratory, School of Medicine, Hunan Normal University, Changsha 410013, China
Jian Chen
Medical Laboratory, The First Affiliated Hospital of Hunan Normal University, Changsha 410018, China
Yiliang Zeng
Shaoshan Changbaitong Biological Technology Co., Ltd., Shaoshan 411100, China
Rushi Liu
Department of Medical Laboratory, School of Medicine, Hunan Normal University, Changsha 410013, China; Corresponding author
Summary: In this study, we evaluated the effect of a specific synbiotic on CAC (AOM/DSS-induced colitis-associated cancer). We confirmed that the synbiotic intervention was able to protect the intestinal barrier and inhibit CAC occurrence via upregulating tight junction proteins and anti-inflammatory cytokines, and downregulating pro-inflammatory cytokines. Moreover, the synbiotic significantly improved the disorder of the colonic microbiota of CAC mice, promoted the formation of SCFAs and the production of secondary bile acids, and alleviated the accumulation of primary bile acids in the CAC mice. Meanwhile, the synbiotic could significantly inhibit the abnormal activation of the intestinal Wnt/β-catenin signaling pathway significantly related to IL-23. In a word, the synbiotic can inhibit the occurrence and development of colorectal tumors and it may be a functional food to prevent inflammation-related colon tumors, and the research also provided a theoretical basis for improving the intestinal microecological environment through diet therapy.
