Molecules
(Nov 2019)
Michael Addition Reaction Catalyzed by Imidazolium Chloride to Protect Amino Groups and Construct Medium Ring Heterocycles
Zeshu Dai,
Qingqiang Tian,
Yanwu Li,
Suqin Shang,
Wen Luo,
Xuetong Wang,
Dan Li,
Ying Zhang,
Zhiyao Li,
Jianyong Yuan
Affiliations
Zeshu Dai
Department of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China
Qingqiang Tian
Department of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China
Yanwu Li
Department of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China
Suqin Shang
Department of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China
Wen Luo
Department of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China
Xuetong Wang
Department of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China
Dan Li
Department of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China
Ying Zhang
Department of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China
Zhiyao Li
Department of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China
Jianyong Yuan
Department of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China
DOI
https://doi.org/10.3390/molecules24234224
Journal volume & issue
Vol. 24,
no. 23
Abstract
Read online
An effective approach for amino protection and construction of a seven-membered ring has been developed. The method uses imidazolium chloride to carry out the Michael addition reaction at low temperatures and perform amino deprotection or construction of a seven-membered ring at high temperatures.
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