Innovative approach to evaluating the correlation between the distribution of the concentration of enzymes in the blood serum and heart tissues of rats

Abstract

Cardiovascular diseases (CVDs) have been the leading cause of death worldwide for many years. In recent years, new CVD markers have been sought that can improve the diagnosis and treatment of this broad and predictably unfavorable group of diseases. The efforts of many researchers are aimed at identifying changes in the level of enzymes in the lipid peroxidation system as possible mechanisms underlying the development of CVDs. The imbalance between the intensification of free-radical oxidation caused by active oxygen forms and the activity of the body’s protective antioxidant system leads to serious disturbances: disorganization of cellular structures, changes in their functional activity. The article presents the study of the interrelations between the concentration distribution of POL-AO enzymes in blood serum and heart tissues of white non-pedigree rats. The correlation coefficients of Spearman, the gamma of correlation and Kendel Tau revealed a reliable presence of weak correlation between the concentration of glutathione peroxidase in blood serum and heart tissues (Spearman R = 0.18 at p < 0.029408, Gamma = 0.14 at p < 0.018701; Kendall Tau = 0.13 at p < 0.018701).