Nature Communications (Aug 2019)
PAX8 activates metabolic genes via enhancer elements in Renal Cell Carcinoma
- Melusine Bleu,
- Swann Gaulis,
- Rui Lopes,
- Kathleen Sprouffske,
- Verena Apfel,
- Sjoerd Holwerda,
- Marco Pregnolato,
- Umut Yildiz,
- Valentina Cordoʹ,
- Antonella F. M. Dost,
- Judith Knehr,
- Walter Carbone,
- Felix Lohmann,
- Charles Y. Lin,
- James E. Bradner,
- Audrey Kauffmann,
- Luca Tordella,
- Guglielmo Roma,
- Giorgio G. Galli
Affiliations
- Melusine Bleu
- Disease Area Oncology, Novartis Institute for Biomedical Research
- Swann Gaulis
- Disease Area Oncology, Novartis Institute for Biomedical Research
- Rui Lopes
- Disease Area Oncology, Novartis Institute for Biomedical Research
- Kathleen Sprouffske
- Disease Area Oncology, Novartis Institute for Biomedical Research
- Verena Apfel
- Disease Area Oncology, Novartis Institute for Biomedical Research
- Sjoerd Holwerda
- Chemical Biology & Therapeutics, Novartis Institutes for Biomedical Research
- Marco Pregnolato
- Disease Area Oncology, Novartis Institute for Biomedical Research
- Umut Yildiz
- Disease Area Oncology, Novartis Institute for Biomedical Research
- Valentina Cordoʹ
- Disease Area Oncology, Novartis Institute for Biomedical Research
- Antonella F. M. Dost
- Disease Area Oncology, Novartis Institute for Biomedical Research
- Judith Knehr
- Chemical Biology & Therapeutics, Novartis Institutes for Biomedical Research
- Walter Carbone
- Chemical Biology & Therapeutics, Novartis Institutes for Biomedical Research
- Felix Lohmann
- Chemical Biology & Therapeutics, Novartis Institutes for Biomedical Research
- Charles Y. Lin
- Department of Molecular and Human Genetics, Baylor College of Medicine
- James E. Bradner
- Novartis Institutes for Biomedical Research
- Audrey Kauffmann
- Disease Area Oncology, Novartis Institute for Biomedical Research
- Luca Tordella
- Disease Area Oncology, Novartis Institute for Biomedical Research
- Guglielmo Roma
- Chemical Biology & Therapeutics, Novartis Institutes for Biomedical Research
- Giorgio G. Galli
- Disease Area Oncology, Novartis Institute for Biomedical Research
- DOI
- https://doi.org/10.1038/s41467-019-11672-1
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 10
Abstract
Transcription factors are critical regulators of cell identity. Here, the authors use computational and functional genomic approaches to show an oncogenic role of PAX8 in renal cancer. Mechanistic dissection of PAX8 functions reveal its role in activating genes associated with metabolic pathways.
