LOW-GRADE FIBROMIXOID SARCOMА OF LOWER LЕG IN YOUNG FEMALE PATIENT- REPORT OF A RARE CASE

Abstract

Low-grade fibromyxoid sarcoma (LGFMS) is a rare soft tissue neoplasm described for the first time by Evans in 1987. It may affect the subcutaneous soft tissues or subfascial space. It usually arises from deeply located soft tissue structures of extremities, head and neck, thorax, and retroperitoneum. We present a case of a female patient of age 24, admitted to the Department of “Surgical Diseases” of Medical University Hospital “D-r G. Stranski” Ltd – Pleven in July 2022, with complaints of a slowly growing non-painful soft mass, located on her right lower leg, distal 1/3 part, anteriorly initially suspected for lipoma. After wide surgical excision grossing and histological and immunohistochemical verification of the specimen, the result was LGFMS G1 pT1. We perform a literature review for another case in the world with that rare tumor. The tumor is with distinct biological behavior. Despite its low grade and benign histological appearance, it has a high potential for metastasizing, years after the primary surgical excision of the tumor, and it has a high risk for local recurrence. Because of the high risk of late metastasis, the follow-up period should be long and monitoring of the lung and chest is mandatory.

Keywords

• soft tissue tumors
• low-grade fibromyxoid sarcoma
• immunohistochemistry