Nature Communications (Jun 2019)
Genomic structure and diversity of Plasmodium falciparum in Southeast Asia reveal recent parasite migration patterns
- Amol C. Shetty,
- Christopher G. Jacob,
- Fang Huang,
- Yao Li,
- Sonia Agrawal,
- David L. Saunders,
- Chanthap Lon,
- Mark M. Fukuda,
- Pascal Ringwald,
- Elizabeth A. Ashley,
- Kay Thwe Han,
- Tin Maung Hlaing,
- Myaing M. Nyunt,
- Joana C. Silva,
- Kathleen E. Stewart,
- Christopher V. Plowe,
- Timothy D. O’Connor,
- Shannon Takala-Harrison,
- Artemisinin Resistance Confirmation, Characterization, and Containment (ARC3),
- Artemisinin Resistance Containment and Elimination (ARCE),
- Tracking Resistance to Artemisinin Collaboration (TRAC)
Affiliations
- Amol C. Shetty
- Institute for Genome Sciences, University of Maryland School of Medicine
- Christopher G. Jacob
- Wellcome Sanger Institute
- Fang Huang
- National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention
- Yao Li
- Center for Geospatial Information Science, University of Maryland
- Sonia Agrawal
- Graduate Program in Epidemiology and Human Genetics, University of Maryland School of Medicine
- David L. Saunders
- Armed Forces Research Institute of Medical Sciences
- Chanthap Lon
- Armed Forces Research Institute of Medical Sciences
- Mark M. Fukuda
- Armed Forces Research Institute of Medical Sciences
- Pascal Ringwald
- Global Malaria Programme, World Health Organization
- Elizabeth A. Ashley
- Mahidol-Oxford Tropical Medicine Research Unit (MORU), Faculty of Tropical Medicine, Mahidol University
- Kay Thwe Han
- Department of Medical Research, Ministry of Health and Sports
- Tin Maung Hlaing
- Defence Services Medical Research Centre
- Myaing M. Nyunt
- Duke Global Health Institute, Duke University
- Joana C. Silva
- Institute for Genome Sciences, University of Maryland School of Medicine
- Kathleen E. Stewart
- Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford
- Christopher V. Plowe
- Duke Global Health Institute, Duke University
- Timothy D. O’Connor
- Institute for Genome Sciences, University of Maryland School of Medicine
- Shannon Takala-Harrison
- Center for Vaccine Development and Global Health, University of Maryland School of Medicine
- Artemisinin Resistance Confirmation, Characterization, and Containment (ARC3)
- Artemisinin Resistance Containment and Elimination (ARCE)
- Tracking Resistance to Artemisinin Collaboration (TRAC)
- DOI
- https://doi.org/10.1038/s41467-019-10121-3
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 11
Abstract
Understanding genomic variation in Plasmodium falciparum parasites and inferring migration patterns can guide malaria elimination strategies. Using genome-wide data for 1722 parasites collected from 54 districts, the authors use identity-by-descent approaches to estimate regional parasite migration and spread of artemisinin drug resistance.
