Nature Communications (Feb 2021)
The Goto-Kakizaki rat is a spontaneous prototypical rodent model of polycystic ovary syndrome
Abstract
Although polycystic ovary syndrome is the most common cause of female infertility, its etiology remains poorly understood. Here, the authors report a rat model that spontaneously exhibits the clinical heterogeneity of this syndrome and demonstrate that the phenotype is developmentally programmed.