Hot-melt co-extrusion technology as a manufacturing platform for anti-hypertensive fixed-dose combinations

Abstract

This work focused on the development of a concentric multi-layered fixed-dose combination via an advanced manufacturing technique, hot-melt co-extrusion. The dosage form was designed to offer differing release behaviour; immediate and sustained release from the coat and core, respectively. Hydrochlorothiazide and losartan potassium were incorporated as anti-hypertensive drugs. Solid-state characterisation revealed that both were transformed into their amorphous forms. In-vitro dissolution testing showed desired release performances offering both immediate and modified release.

Keywords

• hypertension
• hot-melt co-extrusion
• fixed-dose combinations