Effect of mexidol on the lipid peroxidation and antioxidant activity of saliva in patients with periodontitis at the background of hypothyroidism

Abstract

A comparative analysis was carried out concerning the state of the system «lipid peroxidation - antioxidant protection» (POL-AOP) in mixed saliva of patients with chronic periodontitis of mild (n = 22), moderate (n = 20) and severe (n = 18) form at the background of hypothyroidism. As a result of the research it was found that at the background of hypothyroidism there develops an imbalance in the work of all parts of the local system of nonspecific defense of the body, especially at severe periodontitis. And reduction of key enzymes of the antiradical protection (superoxide dismutase and catalase) in mixed saliva is the leading biochemical change that is accompanied by increased inflammation in the periodontium. It is shown that the adaptation increase and AOP therapeutic effect in the shortest term after the use of mexidol is manifested by reducing lipid peroxidation processes, especially in patients with mild periodontitis. Effectiveness of the treatment of moderate and severe periodontitis using mexidol was significantly lower, in comparative aspect.

Keywords

• хронический пародонтит
• гипотиреоз
• смешанная слюна
• перекисное окисление липидов
• антиоксидантная защита
• chronic periodontitis
• hypothyroidism
• mixed saliva
• lipid peroxidation
• antioxidant protection