Aminoacyl chain translocation catalysed by a type II thioesterase domain in an unusual non-ribosomal peptide synthetase

Shan Wang; William D. G. Brittain; Qian Zhang; Zhou Lu; Ming Him Tong; Kewen Wu; Kwaku Kyeremeh; Matthew Jenner; Yi Yu; Steven L. Cobb; Hai Deng

doi:10.1038/s41467-021-27512-0

Nature Communications (Jan 2022)

Aminoacyl chain translocation catalysed by a type II thioesterase domain in an unusual non-ribosomal peptide synthetase

Shan Wang,
William D. G. Brittain,
Qian Zhang,
Zhou Lu,
Ming Him Tong,
Kewen Wu,
Kwaku Kyeremeh,
Matthew Jenner,
Yi Yu,
Steven L. Cobb,
Hai Deng

Affiliations

Shan Wang: Department of Chemistry, University of Aberdeen
William D. G. Brittain: Department of Chemistry, Durham University, Science Site
Qian Zhang: Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (MOE) and Hubei Province Engineering and Technology Research Centre for Fluorinated Pharmaceuticals, School of Pharmaceutical Sciences, Wuhan University
Zhou Lu: Department of Chemistry, University of Aberdeen
Ming Him Tong: Department of Chemistry, University of Aberdeen
Kewen Wu: Department of Chemistry, University of Aberdeen
Kwaku Kyeremeh: Department of Chemistry, University of Ghana
Matthew Jenner: Department of Chemistry, University of Warwick
Yi Yu: Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (MOE) and Hubei Province Engineering and Technology Research Centre for Fluorinated Pharmaceuticals, School of Pharmaceutical Sciences, Wuhan University
Steven L. Cobb: Department of Chemistry, Durham University, Science Site
Hai Deng: Department of Chemistry, University of Aberdeen

DOI: https://doi.org/10.1038/s41467-021-27512-0
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 14

Abstract

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Non-Ribosomal Peptide Synthetases (NRPSs) are responsible for the construction of many types of natural products. Here the authors characterize a key type II thioesterase domain that sheds light on the chain translocation processes of legonmycin NRPSs.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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