Nature Communications (Nov 2022)

Hippocampal astrocytes modulate anxiety-like behavior

  • Woo-Hyun Cho,
  • Kyungchul Noh,
  • Byung Hun Lee,
  • Ellane Barcelon,
  • Sang Beom Jun,
  • Hye Yoon Park,
  • Sung Joong Lee

DOI
https://doi.org/10.1038/s41467-022-34201-z
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 14

Abstract

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Astrocytes affect animal behaviors by regulating the tripartite synapse. Here, the authors show that hippocampal astrocytes modulate mouse anxiety-like behavior by regulating synaptic homeostasis of dentate gyrus granule cells via ATP release.