BST1 regulates nicotinamide riboside metabolism via its glycohydrolase and base-exchange activities

Keisuke Yaku; Sailesh Palikhe; Hironori Izumi; Tomoyuki Yoshida; Keisuke Hikosaka; Faisal Hayat; Mariam Karim; Tooba Iqbal; Yasuhito Nitta; Atsushi Sato; Marie E. Migaud; Katsuhiko Ishihara; Hisashi Mori; Takashi Nakagawa

doi:10.1038/s41467-021-27080-3

Nature Communications (Nov 2021)

BST1 regulates nicotinamide riboside metabolism via its glycohydrolase and base-exchange activities

Keisuke Yaku,
Sailesh Palikhe,
Hironori Izumi,
Tomoyuki Yoshida,
Keisuke Hikosaka,
Faisal Hayat,
Mariam Karim,
Tooba Iqbal,
Yasuhito Nitta,
Atsushi Sato,
Marie E. Migaud,
Katsuhiko Ishihara,
Hisashi Mori,
Takashi Nakagawa

Affiliations

Keisuke Yaku: Department of Molecular and Medical Pharmacology, Faculty of Medicine, University of Toyama
Sailesh Palikhe: Department of Molecular and Medical Pharmacology, Faculty of Medicine, University of Toyama
Hironori Izumi: Department of Molecular Neuroscience, Faculty of Medicine, University of Toyama
Tomoyuki Yoshida: Department of Molecular Neuroscience, Faculty of Medicine, University of Toyama
Keisuke Hikosaka: Department of Molecular and Medical Pharmacology, Faculty of Medicine, University of Toyama
Faisal Hayat: Mitchell Cancer Institute, Department of Pharmacology, University of South Alabama
Mariam Karim: Department of Molecular and Medical Pharmacology, Faculty of Medicine, University of Toyama
Tooba Iqbal: Department of Molecular and Medical Pharmacology, Faculty of Medicine, University of Toyama
Yasuhito Nitta: Department of Molecular and Medical Pharmacology, Faculty of Medicine, University of Toyama
Atsushi Sato: School of Bioscience and Biotechnology, Tokyo University of Technology
Marie E. Migaud: Mitchell Cancer Institute, Department of Pharmacology, University of South Alabama
Katsuhiko Ishihara: Department of Immunology and Molecular Genetics, Kawasaki Medical University
Hisashi Mori: Department of Molecular Neuroscience, Faculty of Medicine, University of Toyama
Takashi Nakagawa: Department of Molecular and Medical Pharmacology, Faculty of Medicine, University of Toyama

DOI: https://doi.org/10.1038/s41467-021-27080-3
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 17

Abstract

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Nicotinamide riboside (NR) is a NAD + precursor exhibiting beneficial effects against aging. Here the authors demonstrate that orally administered NR increases NAD + levels in a diphasic manner and that bone marrow stromal cell antigen 1 plays a crucial role for NAD + synthesis from NR.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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