Anais Brasileiros de Dermatologia (Mar 2017)

Do you know this syndrome? Werner syndrome

  • Özlem Bilgiç

DOI
https://doi.org/10.1590/abd1806-4841.20174640
Journal volume & issue
Vol. 92, no. 2
pp. 271 – 272

Abstract

Read online Read online

Abstract: Werner syndrome is a rare autosomal recessive disorder, caused by mutations in the WRN gene. Clinical findings include: senile appearance, short stature, grey hair, alopecia, bird-like face, scleroderma-like skin changes, skin ulcers, voice abnormalities, cataracts, osteoporosis, type 2 diabetes mellitus, ischemic heart disease and hypogonadism. The syndrome begins to become apparent in adolescence but it is usually diagnosed in the third or fourth decade of life. Since the patients usually die by the age of 40-50 years related to malignant neoplasms or atherosclerotic complications, they should be closely followed and treated for complications

Keywords