A short synthesis of (±)-cherylline dimethyl ether

Abstract

A synthesis of (±)-cherylline dimethyl ether is reported. The key steps involved are Michael-type addition, radical azidonation of an aldehyde, Curtius rearrangement, and reduction of an isocyanate intermediate followed by Pictet–Spengler cyclization.

Keywords

• Curtius rearrangement
• Michael reaction
• Pictet–Spengler cyclization
• radical azidonation